Workers - Hazard for the eyes Additional information - workers Read-across approach for lead containing glass, oxide, chemicals: The test item is covered under the definition "glass".
Thus, the available analytical information is only of quantitative nature without any indication as to elemental composition or structural purposes. For this reason, read-across is anticipated to lead monoxide as a moderately soluble lead substance.
This read-across is considered justified and also conservative since lead monoxide water solubility approx.
After 28 days, the dissolution of Pb ranged from Based on the nominal test item amount, the maximum dissolution of Pb at pH 6 from the test item corresponded to 6. At pH 8, the maximum dissolution of Pb after 24 h based on contained Pb was 3.
Test material with a PbO content of After 28 days, the dissolution of Pb ranged from ± 8. At pH 6, the maximum dissolution of Pb from the test item was Based on contained Pb, the dissolution corresponded to At pH 8, the maximum dissolution of Pb after 24 h based on contained Pb was In comparison, a water solubility of lead monoxide saturation solubility, OECD ; Heintze of is given with Based on the above data, the release of Pb fromthe test item glass, oxide, chemicals is substantial, but eithersimilar or lower compared to pure PbO.
Thus, read-across to lead monoxide can be considered scientifically justified and sufficiently conservative.
Correction of dose descriptors is not needed since data are based site- ul de dating pentru iq low a systemic measure of exposure lead in blood in humans that eliminates the need for route to route extrapolations or other corrections to the dose descriptors. The toxicity of systemic lead is mediated by the lead cation and is independent of the original speciation of the lead compound to which exposure occurred.
For inorganic lead and its' compounds, toxicity indexed to internal blood lead can generally be evaluated independent of the speciation of the compound to which exposure originally occurred.
This has permitted detailed evaluation of issues such as age, gender, ethnicity, intensity of exposure and duration of exposure that can be sources of uncertainty in effects assessment. Separate 3.